Shiitake Organic Extract

Organic Shiitake Extract – supports immunity, cellular protection, and cardiovascular health

Shiitake (Lentinula edodes) is one of the most highly regarded medicinal mushrooms in Asian tradition, used for centuries both as a food and as a natural ingredient to support health. Shiitake extract is rich in bioactive polysaccharides, beta-glucans, and lentinan—compounds studied for their role in supporting the immune system.

Doctor Cip’s Organic Shiitake Extract contains 100% pure, concentrated organic extract from Lentinula edodes, standardized to 30% bioactive polysaccharides. The formula contains no mycelium powder or ground mushrooms, only concentrated active extract, supplemented with organic acerola extract.

How does Organic Shiitake Extract help you?

• Supports the immune system and the body's natural defenses.
• It supports the cellular immune response by providing bioactive polysaccharides and beta-glucans.
• Helps protect cells against oxidative stress.
• Supports cardiovascular health and metabolic balance.
• It may help maintain normal cholesterol levels as part of a healthy lifestyle.
• Supports blood circulation and vascular health.
• It contains lentinan, a beta-glucan found specifically in shiitake mushrooms, which has been studied for its immunomodulatory effects.
• It can help support the body during periods of exhaustion, stress, or recovery.
• It helps maintain vitality and overall well-being.
• Supports inflammatory balance by modulating the immune response.
• It can be incorporated into complementary regimens alongside AHCC, Reishi, Maitake, Cordyceps, or vitamin D3.
• It is suitable for vegans and vegetarians.

How does Shiitake work?

The main active compounds in shiitake mushrooms are bioactive polysaccharides, particularly beta-glucans. These interact with certain immune system cells, such as macrophages, dendritic cells, and lymphocytes, helping to better coordinate the immune response.

Lentinan, one of the best-known beta-glucans found in shiitake mushrooms, has been studied for its immunomodulatory effects. It does not act as an aggressive immune stimulant, but rather as a biological modulator, supporting the body’s ability to respond appropriately to external challenges.

Shiitake also contains compounds such as eritadenine, which has been linked in experimental studies to cholesterol metabolism. Through its combination of polysaccharides, fiber, antioxidants, and bioactive compounds, shiitake extract can simultaneously support immunity, cardiovascular health, and cellular protection.

What do clinical studies show?

Shiitake is one of the most extensively studied medicinal mushrooms, particularly for its effects on the immune system. Research has examined the consumption of shiitake and extracts rich in beta-glucans to assess their impact on immunity, inflammation, immunological markers, and lipid metabolism.

A study published in the Journal of the American College of Nutrition (2015), conducted by Dai X. and colleagues, evaluated the daily consumption of shiitake mushrooms in healthy adults over a 4-week period. The researchers observed improvements in certain markers of immune function, including increased production of secretory IgA and favorable changes in the activity of cells involved in the immune response.
View the study

A review published in *Foods* (2023) discussed the properties of lentinan and beta-glucans extracted from shiitake mushrooms, highlighting their role in modulating the immune response and supporting inflammatory balance.
See the review

A review published in the International Journal of Molecular Sciences (2021) described how beta-glucans from mushrooms can influence the immune response, including through interaction with macrophages, NK cells, and other components of the innate immune system.
See the analysis

Experimental studies have also investigated the compound eritadenine found in shiitake mushrooms, which is associated with cholesterol metabolism and effects on the lipid profile. These findings support the interest in shiitake as a functional food and natural extract for cardiovascular health.
View the study

• Journal of the American College of Nutrition, 2015 – Daily Consumption of Lentinula edodes (Shiitake) Mushrooms Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults (Dai X. et al.)
• Foods, 2023 – Lentinan and β-glucan extract from shiitake mushrooms: immunomodulatory and biological effects.
• International Journal of Molecular Sciences, 2021 – Beta-Glucans from Fungi: Biological and Health-Promoting Potential.
• Journal of Agricultural and Food Chemistry, 2007 – Quantification of eritadenine, a bioactive compound from the shiitake mushroom.

Why Choose Doctor Cip’s Organic Shiitake Extract?

• 100% pure and concentrated organic extract from the Shiitake mushroom (Lentinula edodes).
• Standardized to contain 30% bioactive polysaccharides, ensuring a consistent level of active compounds.
• 600 mg of organic shiitake extract per daily dose of 2 capsules.
• 180 mg of bioactive polysaccharides per daily dose.
• Contains organic acerola extract, a natural source of vitamin C.
• No mycelium powders or ground mushrooms —just concentrated active extract.
• Vegetarian capsules, suitable for vegans and vegetarians.
• Contains no gluten or lactose.

Ingredients and directions for use

Composition per daily dose (2 capsules)

• Organic Shiitake extract (Lentinula edodes) – 600 mg
• Of which bioactive polysaccharides – 180 mg
• Organic acerola extract (Malpighia glabra) – 40 mg

The bottle contains 60 vegetarian capsules, suitable for vegan and vegetarian diets, with no gluten or lactose.

How to use

The recommended dose is 2–4 capsules per day, preferably in the morning on an empty stomach, or as directed by a healthcare professional.

To support the immune system, it is recommended to take it regularly for at least 2–3 months, depending on your specific goal and your healthcare provider’s advice.

Atenționări

People with autoimmune conditions, those on immunosuppressive therapy, or patients undergoing complex treatments should consult their doctor before use.

People who are allergic to mushrooms or mushroom-derived products should avoid using this product or consult a doctor before use.

During the first few days of use, some people may experience mild digestive discomfort, bloating, or temporary changes in bowel movements.

Pregnant or breastfeeding women, children, and people with chronic medical conditions should consult a doctor before use.

Dietary supplements do not cure diseases and cannot replace treatments prescribed by a doctor. Do not exceed the recommended daily dose. Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.